Remote Ischemic Preconditioning for Prevention of High Altitude Diseases : Fact or Fiction ? 1 Marc
نویسندگان
چکیده
Remote Ischemic Preconditioning for Prevention of High Altitude Diseases: Fact or Fiction? 1 Marc Moritz Berger, Franziska Macholz, Heimo Mairbäurl, Peter Bärtsch 2 3 1) Department of Anesthesiology, Perioperative and General Critical Care Medicine, Salzburg General 4 Hospital, Paracelsus Medical University, Salzburg, Austria. 5 2) Department of Anesthesiology, University of Heidelberg, Germany 6 3) Department of Internal Medicine VII, Division of Sports Medicine, University of Heidelberg, 7 Germany 8 4) Translational Lung Research Center Heidelberg (TLRC-H; part of the German Center for Lung 9 Research, DZL) 10 11 12 13 14 15 16 17 18 19 Corresponding author 20 Marc Moritz Berger, MD, DESA 21 Department of Anesthesiology, Perioperative and General Critical Care Medicine 22 Salzburg General Hospital 23 Paracelsus Medical University 24 Müllner Hauptstrasse 48 25 A-5020 Salzburg 26 Phone: +43 662 4482 57794, Fax: +43 662 4482 2703 27 e-mail: [email protected] 28 29 30 31 32 Articles in PresS. J Appl Physiol (June 18, 2015). doi:10.1152/japplphysiol.00156.2015
منابع مشابه
Remote ischemic preconditioning for prevention of high-altitude diseases: fact or fiction?
Preconditioning refers to exposure to brief episodes of potentially adverse stimuli and protects against injury during subsequent exposures. This was first described in the heart, where episodes of ischemia/reperfusion render the myocardium resistant to subsequent ischemic injury, which is likely caused by reactive oxygen species (ROS) and proinflammatory processes. Protection of the heart was ...
متن کاملInvestigating the role of acute and repeated stress on remote ischemic preconditioning-induced cardioprotection
Objective(s): To study the effect of acute and repeated stress on cardioprotection-induced by remote ischemic preconditioning (RIPC).Materials and Methods: RIPC was induced by giving 4 short cycles of ischemia and reperfusion, each consisting of five min. The Langendorff’s apparatus was used to perfuse the isolated rat hearts by subjecti...
متن کاملIschemic preconditioning for prevention of contrast medium-induced nephropathy: randomized pilot RenPro Trial (Renal Protection Trial).
BACKGROUND Contrast medium-induced acute kidney injury is associated with substantial morbidity and mortality. The underlying mechanism has been attributed in part to ischemic kidney injury. The aim of this randomized, double-blind, sham-controlled trial was to assess the impact of remote ischemic preconditioning on contrast medium-induced acute kidney injury. METHODS AND RESULTS Patients wit...
متن کاملLiver ischemia preconditions the heart against ischemia-reperfusion arrhythmias
Objective(s):This study aimed to examine the hypothesis that an antiarrhythmic effect might be obtained by ischemic preconditioning of the liver, and also to characterize the potential underlying mechanisms. Materials and Methods: Male Wistar rats were anesthetized by thiopental sodium (50 mg/kg, IP) followed by IV injection of heparin (250 IU). Remote ischemic preconditioning (RIPC) was induce...
متن کاملEffects of remote limb ischemic preconditioning on pulmonary function tests and maximal oxygen uptake
Introduction: Ischemic preconditioning (IPC) protects skeletal muscles from ischemia-reperfusion injury and improves physical exercise performance. The purpose of the present study was to determine whether application of remote ischemic preconditioning (RIPC) of upper limbs would affect the pulmonary function tests and the maximal oxygen consumption (VO2max). Methods: Twenty healthy trained...
متن کامل